Sedangkan penantang juara dunia, Fabio Quartararo menduduki posisi keempat. Kemudian Francesco Bagnaia belum menemukan performa terbaiknya dan menepati peringkat ketujuh
Hasil Latihan Bebas 3 MotoGP Valencia 2022:
1 Jack Miller AUS Ducati Lenovo (GP22)
2 Johann Zarco FRA Pramac Ducati (GP22)
3 Brad Binder RSA Red Bull KTM (RC16)
4 Fabio Quartararo FRA Monster Yamaha (YZR-M1)
5 Marc Marquez SPA Repsol Honda (RC213V)
6 Aleix Espargaro SPA Aprilia Factory (RS-GP)
7 Francesco Bagnaia ITA Ducati Lenovo (GP22)
8 Joan Mir SPA Suzuki Ecstar (GSX-RR)
9 Alex Rins SPA Suzuki Ecstar (GSX-RR)
10 Enea Bastianini ITA Gresini Ducati (GP21)
11 Franco Morbidelli ITA Monster Yamaha (YZR-M1)
12 Miguel Oliveira POR Red Bull KTM (RC16)
13 Jorge Martin SPA Pramac Ducati (GP22)
14 Luca Marini ITA Mooney VR46 Ducati (GP22)
15 Maverick Viñales SPA Aprilia Factory (RS-GP)
16 Alex Marquez SPA LCR Honda (RC213V)
17 Pol Espargaro SPA Repsol Honda (RC213V)
18 Remy Gardner AUS KTM Tech3 (RC16)*
19 Takaaki Nakagami JPN LCR Honda (RC213V)
20 Fabio Di Giannantonio ITA Gresini Ducati (GP21)*
21 Cal Crutchlow GBR WithU RNF Yamaha (YZR-M1)
22 Marco Bezzecchi ITA Mooney VR46 Ducati (GP21)*
23 Darryn Binder RSA WithU RNF Yamaha (YZR-M1)*
24 Raul Fernandez SPA KTM Tech3 (RC16)*